Current Studies

Biospecimen Collection and Donation to the AIDS and Cancer Specimen Resource (ACSR): A Companion Protocol to AMC Trials

Tissue Acquisition for Analysis of Prognostic Factors, Immunology, and Genetic Progression of HIV-1 Associated Malignancies

A Feasibility Study of Glofitamab plus Chemoimmunotherapy in Newly Diagnosed HIV-Associated Large B-Cell Lymphoma

Epcoritamab in Combination with Dose Adjusted EPOCH-R for High-risk Burkitt Lymphoma (BL) (BEDROCK Study)

Administration of HIV-specific T cells to HIV+ Patients Receiving High Dose Chemotherapy Followed by Autologous Stem Cell Rescue -Auto-RESIST

Axicabtagene Ciloleucel in Relapsed or Refractory HIV-Associated Aggressive B-Cell Non-Hodgkin Lymphoma

Observational Cohort Study of People Living with HIV Treated with CD19-Directed CAR T Cell Therapy for B-Cell Lymphoid Malignancies

A Phase I Study of Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-Selected CD34+ Cells

Phase I and Dose-Expansion Study of Ibrutinib and R-da-EPOCH for Front Line Treatment of AIDS-Related Lymphomas

A Multicenter, Open-label Feasibility Study of Daratumumab with Dose-Adjusted EPOCH in Newly Diagnosed Plasmablastic Lymphoma

Phase II Study of Response-Adapted Therapy Using Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy Comprising ABVD With Versus Without Combination Chemotherapy Comprising Standard or Escalated BEACOPP in Patients with Stage III-IV Hodgkin Lymphoma

Phase I and Pharmacokinetic Study of Ibrutinib in HIV-Infected Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Multiple Myeloma

Phase II Study of Dose-Adjusted EPOCH+/- Rituximab in Adults with Untreated Burkitt Lymphoma, C-Myc Positive Diffuse Large B-Cell Lymphoma and Plasmablastic Lymphoma

A Phase 1/2 Study Examining AVD and Brentuximab Vedotin in Patients with HIV and Advanced Stage Hodgkin's Lymphoma

Allogeneic Hematopoietic Cell Transplant for Hematological Cancers and Myelodysplastic Syndromes in HIV-Infected Individuals

Quantification of HIV-1 Reservoirs in HIV-Positive Persons Receiving Response-Adapted Therapy for Stage III-IV Hodgkin Lymphoma: A Companion Protocol to SWOG Protocol S0816 (AMC-073)

A Sequential Phase I/Randomized Phase II Trial of Vorinostat and Risk-Adapted Chemotherapy with Rituximab in HIV-Related B-cell Non-Hodgkin’s Lymphoma

High Dose Chemotherapy with Autologous Stem Cell Rescue for Aggressive B Cell Lymphoma and Hodgkin Lymphoma in HIV-infected Patients

Randomized, Phase II Trial of CHOP vs. Oral Chemotherapy with Concomitant Antiretroviral Therapy in Patients with HIV-associated Lymphoma in Sub-Saharan Africa

Safety And Efficacy Trial Of The Anti-Viral And Anti-Tumor Activity Of Velcade Combined With (R) ICE In Subjects With Relapsed/Refractory AIDS-Associated Lymphoma

Phase II Trial Of ESHAP (Etoposide, Methylprednisolone, Cytosine Arabinoside, And Cisplatin) Followed By Zevalin As Consolidation Therapy In Relapsed/Refractory AIDS-Related Lymphomas

Phase II Multicenter Study of Pomalidomide Monotherapy in HIV-Infected Individuals with Kaposi Sarcoma (KS) in Sub-Saharan Africa

A Phase 2 Trial of Ixazomib for Kaposi Sarcoma

Multicenter Phase II Study of Pomalidomide Monotherapy in Kaposi Sarcoma

A Phase III, Randomized, Open-Label, Non-Inferiority Study of Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma in Resource-Limited Settings

Phase II Multicenter Study of Pomalidomide Monotherapy in HIV-Infected Individuals with Kaposi Sarcoma (KS) in Sub-Saharan Africa

A Pilot Study of Nelfinavir for the Treatment of Kaposi Sarcoma

A Phase II Study of sEphB4-HSA in Kaposi Sarcoma

Nelfinavir for the Treatment of AIDS KS

A Phase I/Pharmacokinetic Study of Erlotinib for Advanced Non-Small Cell Lung Cancer in Persons with HIV Infection

A Phase I/II Study of Gamma Secretase Inhibitor PF-03084014 in Patients with AIDS-Associated Kaposi's Sarcoma

Pharmacology Substudies of A5263 and A5264

A Phase I/II Study of Lenalidomide in Patients with AIDS-Associated Kaposi’s Sarcoma

A Randomized Comparison of Antiretroviral Therapy Alone or with Delayed Chemotherapy versus Antiretroviral Therapy with Immediate Adjunctive Chemotherapy for Treatment of Limited Stage AIDS-KS in Resource-Limited Settings

A Randomized Comparison of Three Regimens of Chemotherapy with Compatible Antiretroviral Therapy for Treatment of Advanced AIDS-KS in Resource-Limited Settings

Single-Arm, Dose-Finding Pilot Trial of Single-Agent Bortezomib in Patients with Relapsed/Refractory Aids-Associated Kaposi Sarcoma with Correlative Assessments of KSHV and HIV

Pilot Study Of Viral Load And Transcription In Kaposi's Sarcoma Patients Treated With Liposomal Anthracyclines

A Phase I & II  Trial of  VEGF- Antisense Oligenucleotide (VEGF-AS)  in Patients with HIV Related Kaposi's Sarcoma

A Phase II Study of Propranolol for the Treatment of Kaposi Sarcoma in Children and Adults

Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living with HIV: A Feasibility Study

Use of a Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in the AMC

Feasibility Study of Ocular Surface Squamous Neoplasia (OSSN) Surgical Excision in People Living with HIV in Sub-Saharan Africa (SSA)

Risk Adapted Therapy for HIV-Associated Anal Cancer

Incidence of HIV and Other STI Among Indian Men Who Have Sex with Men (MSM)

HPV-Related Neoplasia Among HIV-Seropositive Indian Men Who Have Sex with Men (MSM)

Phase IIB Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Paclitaxel and Carboplatin in HIV-Infected Women with Locally Advanced Cervical Cancer (LACC)

HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients With HIV and HPV (COVENANT)

Anal Cancer/HSIL Outcomes Research (ANCHOR) Study

A Phase 2 Evaluation of VGX-3100, a Synthetic DNA Immunotherapy Targeting Human Papillomavirus 16 and 18 E6 and E7 Proteins, for Anal High-Grade Squamous Intraepithelial Lesions (HSIL) in HIV-Positive Individuals

A multicenter observational and feasibility study of excision of superficially invasive squamous cell carcinoma (SISCCA) of the anal canal and perianus in HIV-infected persons

A Randomized Phase III Study of Intra-anal Imiquimod 2.5% vs. Topical 5-Fluorouracil 5% vs. Observation for the Treatment of High-grade Squamous Anal Intraepithelial Lesions (HSIL) in HIV-infected Men and Women

Improving Participation in AMC Clinical Trials (IMPACTS)

Screening HIV-Infected Women for Anal Cancer Precursors

Feasibility Study of Safety, Toxicity, and Compliance of Concomitant Chemoradiotherapy for HIV-Associated Locally-Advanced Cervical Cancer

A Randomized Clinical Trial of Infrared Coagulation (IRC) Ablation versus Expectant Management of Intra-Anal High Grade Intraepithelial Neoplasia (HGAIN) in HIV-infected Subjects

Prospective Observational Study of Site-Specific Incident and Prevalent Cases of Cancer in People Living with HIV/AIDS- in Latin America

Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex with Males

A Companion Protocol To Evaluate Anogenital Human Papillomavirus (HPV) Infection And Anogenital Squamous Intraepithelial Lesions (ASIL) In Patients Participating In AMC Clinical Trials